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Genomic and immune profiling of breast cancer brain metastases

12 May 2025

Abstract excerpt

BACKGROUND: Brain metastases (BrM) arising from breast cancer (BC) are an increasing consequence of advanced disease, with up to half of patients with metastatic HER2 + or triple negative BC experiencing central nervous system (CNS) recurrence. The genomic alterations driving CNS recurrence, along with contributions of the immune microenvironment, particularly by intrinsic subtype, remain unclear. METHODS: We...

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PMID: 40355907
DOI: 10.1186/s40478-025-02001-3

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