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Article

Mapping molecular subtype specific alterations in breast cancer brain metastases identifies clinically relevant vulnerabilities.

Nature communications - 26 Jan 2022

Cosgrove Nicola, Varešlija Damir, Keelan Stephen, Elangovan Ashuvinee, Atkinson Jennifer M, Cocchiglia Sinéad, Bane Fiona T, Singh Vikrant, Furney Simon, Hu Chunling, Carter Jodi M, Hart Steven N, Yadav Siddhartha, Goetz Matthew P, Hill Arnold D K, Oesterreich Steffi, Lee Adrian V, Couch Fergus J, Young Leonie S

Abstract excerpt

The molecular events and transcriptional plasticity driving brain metastasis in clinically relevant breast tumor subtypes has not been determined. Here we comprehensively dissect genomic, transcriptomic and clinical data in patient-matched longitudinal tumor samples, and unravel distinct transcriptional programs enriched in brain metastasis. We report on subtype specific hub genes and functional processes,...

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Identifiers

PMID: 35082299
DOI: 10.1038/s41467-022-27987-5
PMCID: PMC8791982

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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