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Article

The effect of SGLT2 inhibitor on the gene expression and metabolomic profile of podocytes

2026-02-07

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> Podocyte injury due to hyperglycemia is a key driver of diabetic kidney disease (DKD). Although sodium-glucose co-transporter 2 inhibitor (SGLT2i) act primarily on the proximal tubule, they may have direct effects on podocyte. We investigated the effect of dapagliflozin on the transcriptomic and metabolomic profiles of cultured human podocytes under high gluco...

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Literature Corpus work
995f4734-d04c-544e-b8e7-9d56b2164395
DOI
10.21203/rs.3.rs-8696910/v1
Open publication

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The effect of SGLT2 inhibitor on the gene expression and metabolomic profile of podocytesDOI 10.21203/rs.3.rs-8696910/v1
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