Back to search

Article

Efficacy and Safety of SGLT2 Inhibitors in the Treatment of Type 2 Diabetes: An Umbrella Review

2025-12-01

Abstract excerpt

<h4>Objective</h4> While sodium-glucose co-transporter 2 (SGLT2) inhibitors offer a novel, insulin-independent approach to managing type 2 diabetes (T2DM), their overall benefit-risk profile, encompassing cardio-renal outcomes and long-term safety, requires a comprehensive synthesis of the evidence. This umbrella review aims to definitively evaluate the efficacy and safety of SGLT2 inhibitors in patients with T2D...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
b0ac6a91-257a-5504-882a-4aacc4611a08
DOI
10.1101/2025.11.27.25341177
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Efficacy and Safety of SGLT2 Inhibitors in the Treatment of Type 2 Diabetes: An Umbrella ReviewDOI 10.1101/2025.11.27.25341177
The Efficacy and Safety of SGLT2 Inhibitors in Diabetes Kidney Transplant Recipients: A Systematic Review and Meta-AnalysisSemantic proximity
Effect of SGLT-2 Inhibitors on Cardiovascular Outcomes Among Patients With Heart Failure and Type 2 Diabetes Mellitus: A Systemic Review and Meta-Analysis of Randomized Controlled TrialsSemantic proximity
Comparative Effectiveness of Second-line Antihyperglycemic Agents for Cardiovascular Outcomes: A Large-scale, Multinational, Federated Analysis of the LEGEND-T2DM StudySemantic proximity
Cardiorenal outcomes of tirzepatide versus semaglutide in adults with type 2 diabetes and chronic kidney disease: a target trial emulation in the TriNetX Global Collaborative NetworkSemantic proximity
Effect of SGLT2 Inhibitors on CKD Progression and All-Cause Mortality: A Meta-Analysis of Randomized Controlled TrialsSemantic proximity
Efficacy and Safety of Sodium-Glucose Cotransporter 2 Inhibitors in the Very Elderly with Chronic Kidney Disease: a Retrospective Cohort Study Using Real-World DataSemantic proximity
Kidney outcomes with SGLT2 inhibitors in patients with diabetes and an insulin-deficient phenotype: A real world analysis.Semantic proximity
Extraglycemic effects of sodium glucose cotransporter 2 inhibitors with a systemic approach, from possibilities to certaintySemantic proximity
Heterogeneity of Treatment Effects of Glucose-lowering Drug Classes for Type 2 Diabetes: LEGEND-T2DM Network Real-World EvidenceSemantic proximity
Efficacy and safety of SGLT2 inhibitors in the treatment of heart failure-May raise creatinine levels in patients: A meta-analysisSemantic proximity
Safety and effectiveness of SGLT2-inhibitors in people with type 2 diabetes over 70: UK population-based study using an Instrumental Variable approachSemantic proximity
Current progress in pharmacogenomics of Type 2 diabetes: A systemic overview.Semantic proximity
Select a neighboring publication to make it the new centre.