Article

Dapagliflozin improves early diabetic nephropathy by downregulating PPP2R2A and CXCL12/S100A13 through ROS- dependent

2022-05-10

Abstract excerpt

Diabetic nephropathy (DN) is a common chronic complication of diabetes mellitus (DM), and dapagliflozin, a representative drug of sodium-glucose co-transport protein 2 inhibitors (SGLT2i), is a novel hypoglycemic agent for the treatment of type 2 diabetes mellitus (T2DM), which has been shown to reverse microalbuminuria in early type 2 diabetic nephropathy (T2DN), but the mechanism of action remains to be elucidat...

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Literature Corpus work: ed8c4365-6d14-5337-b51d-a7eba375296b
DOI: 10.21203/rs.3.rs-1511213/v1

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