Back to search

Article

Macrophage Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer

2018-11-05

Abstract excerpt

<h4>Summary</h4> Pancreatic Ductal Adenocarcinoma (PDA) is characterized by abundant infiltration of tumor associated macrophages (TAMs). TAMs have been reported to drive resistance to gemcitabine, the front-line chemotherapy in PDA, though the mechanism of this resistance remains unclear. Profiling metabolite exchange, we demonstrate macrophages programmed by PDA cells release a spectrum of pyrimidine species. T...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
9930e1f4-0ba1-5881-bd89-2898eb1bc0b9
DOI
10.1101/463125
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Macrophage Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic CancerDOI 10.1101/463125
Macrophage-secreted Pyrimidine Metabolites Confer Chemotherapy Resistance in Acute Myeloid Leukemia (AML)Semantic proximity
Mevalonate Biosynthesis is a Metabolic Vulnerability of Gemcitabine-resistant Pancreatic CancerSemantic proximity
An Engineered 3D Co-culture Model of Primary Macrophages and Patient-Derived Tumour Cells to Explore Cellular Responses in the Graded Hypoxic Microenvironment of Pancreatic CancerSemantic proximity
Indirect pharmacology of Amorphophallus rivieri Durieu in pancreatic ductal adenocarcinoma: immune-dependent macrophage remodeling and amino acid-related metabolic alterationsSemantic proximity
Defining the spatial distribution of extracellular adenosine revealed a myeloid-dependent immunosuppressive microenvironment in pancreatic ductal adenocarcinomaSemantic proximity
Uridine-derived ribose fuels glucose-restricted pancreatic cancerSemantic proximity
Pancreatic cancer extracellular vesicles carry a time-of-day-regulated miRNA cargo that disrupts the skeletal muscle clock and bioenergeticsSemantic proximity
Mono-ADP-ribosylation-driven immunosuppression and cross-resistance to therapy through cancer cell intrinsic and extrinsic mechanismsSemantic proximity
ELOVL6 as a Therapeutic Target: Disrupting c-MYC-Driven Lipid Metabolism to Enhance Chemotherapy in Pancreatic CancerSemantic proximity
Treatment of Elderly Patients with Advanced Pancreatic Ductal Adenocarcinoma Utilizing a Metronomic Dose and Schedule of Chemotherapy: A Better ApproachSemantic proximity
De novo pyrimidine biosynthesis inhibition synergizes with BCL-X <sub>L</sub> targeting in pancreatic cancerSemantic proximity
De novo pyrimidine biosynthesis inhibition synergizes with BCL-XL targeting in pancreatic cancerSemantic proximity
Select a neighboring publication to make it the new centre.