Article

A colorectal cancer organoid-CAF co-culture chip for drug screening and personalized therapy

2026-06-19

Abstract excerpt

The tumor microenvironment (TME) plays a critical role in cancer progression and therapeutic response, with cancer-associated fibroblasts (CAFs) being a key stromal component. Conventional tumor organoid models lack TME elements, and existing co-culture systems have limitations in recapitulating dynamic, multidimensional interactions. Here, we developed a novel dynamic co-culture chip (BAC) to better model the TME...

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Literature Corpus work: 61f2a76c-dec5-5e94-b20e-2f49636a9544
DOI: 10.64898/2026.06.15.732195

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