Article

Glial Fibrillary Acidic Protein in Cerebrospinal Fluid of Nusinersen-Treated Patients with Spinal Muscular Atrophy

2021-12-09

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>Activated astroglia is involved in the pathophysiology of neurodegenerative diseases and has also been described in animal models of spinal muscular atrophy (SMA). Given the urgent need of biomarkers for treatment monitoring of new RNA-modifying and gene replacement therapies in SMA, we examined glial fibrillary acidic protein (GFAP) concentrations as a marker of...

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Literature Corpus work: 98ce5291-cec0-5a8a-b9ca-d6edd2c06610
DOI: 10.21203/rs.3.rs-1116872/v1

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