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Article

Symmetric stimulation of Hsp90 catalyzed ATP hydrolysis through enhanced active site gate dynamics.

The Journal of biological chemistry - 1 Jun 2025

Magnan Breanna, Dumont Thomas, Rashid Suad, LaPointe Paul, Spyracopoulos Leo

Abstract excerpt

Heat shock protein 90 (Hsp90) is a vital molecular chaperone that is essential for activating a diverse array of regulatory proteins through an ATP-dependent clamping cycle. The Hsp90 clamping cycle is driven by large-amplitude conformational changes within the N-terminal ATPase domain, including the release of an autoinhibitory N-terminal β-strap followed by a less well-characterized ATP gate rearrangement...

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Identifiers

PMID: 40409552
DOI: 10.1016/j.jbc.2025.110262
PMCID: PMC12205646

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