Article

Physiological System Dysregulation in Gene Expression Correlates Negatively with Age

2020-09-11

Abstract excerpt

We attempted to identify gene expression systems that dysregulate with age in human peripheral blood samples across five public datasets. Dysregulation of gene ontology (GO)-defined systems was measured using the Mahalanobis distance (D M ), a measure of multivariant aberrance. We expected many weak positive D M -age correlations, indicating loss of homeostatic control. Out of the 5180 GO terms tested, we found...

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Literature Corpus work: 983ecc82-bdbe-5fad-835d-883b83f431cd
DOI: 10.1101/2020.09.09.289389

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