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Article

Structural basis for activation of an integral membrane protease by lipopolysaccharide.

The Journal of biological chemistry - 6 Jul 2012

Eren Elif, van den Berg Bert

Abstract excerpt

Omptins constitute a unique family of outer membrane proteases that are widespread in Enterobacteriaceae. The plasminogen activator (Pla) of Yersinia pestis is an omptin family member that is very important for development of both bubonic and pneumonic plague. The physiological function of Pla is to cleave (activate) human plasminogen to form the plasma protease plasmin. Uniquely, lipopolysaccharide (LPS) is...

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Identifiers

PMID: 22645135
DOI: 10.1074/jbc.M112.376418
PMCID: PMC3390672

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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