Article

Synthesis of New Polyfluoro Oligonucleotides via Staudinger Reaction

2024-12-11

Abstract excerpt

Nowadays, nucleic acid derivatives capable of modulating gene expression at the RNA level gained widespread recognition as promising therapeutic agents. A suitable degree of biological stability of oligonucleotide therapeutics that is required for in vivo application can be most expeditiously achieved by chemical modification of the internucleotidic phosphate group, which may also affect their cellular uptake, tis...

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Literature Corpus work: 98187060-4074-51a3-9fc2-03fc54d3333f
DOI: 10.20944/preprints202412.0923.v1

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