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Article

Labelled Oligonucleotides as Radiopharmaceuticals: Pitfalls, Problems and Perspectives

1 Jul 2002

Abstract excerpt

The labelling of single-stranded oligonucleotides with a positron or single-photon emitter can result in valuable radiopharmaceuticals with promising applications for: (i) Imaging of specific mRNAs, i.e. visualisation of the expression of specific genes in vivo (ii) Monitoring of antisense chemotherapy, i.e. measuring the efficiency of efforts to block the expression of specific genes; (iii) Gene radiotherapy,...

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PMID: 12052206
DOI: 10.2174/1381612023394467

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