Article

Affected cell types for hundreds of Mendelian diseases revealed by analysis of human and mouse single-cell data

2022-10-31

Abstract excerpt

<h4>ABSTRACT</h4> Hereditary diseases manifest clinically in certain tissues, however their affected cell types typically remain elusive. Single-cell expression studies showed that overexpression of disease-associated genes may point to the affected cell types. Here, we developed a method that infers disease-affected cell types from the preferential expression of disease-associated genes in cell types (PrEDiCT)....

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Literature Corpus work: 98030c07-0980-5340-8f95-4f4868152d40
DOI: 10.1101/2022.10.29.513906

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