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Article

YAP1 is a key regulator of EWS::FLI1-dependent malignant transformation upon IGF-1 mediated reprogramming of bone mesenchymal stem cells

2024-07-18

Abstract excerpt

<h4> Abstract </h4> Ewing sarcoma (EwS) is an aggressive cancer of adolescents in need of effective treatments. Insulin like growth factor (IGF) 1 was previously reported an autocrine growth factor for EwS, but only 10% of patients responded to IGF-1 receptor blockade. Although presumed to originate from mesenchymal progenitors during bone development, targeting of the EwS driver oncogene EWS::FLI1 to the mesen...

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Literature Corpus work
97c9341b-e6e1-52e8-9d59-58b9b1ae30a8
DOI
10.1101/2024.07.15.603565
Open publication

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YAP1 is a key regulator of EWS::FLI1-dependent malignant transformation upon IGF-1 mediated reprogramming of bone mesenchymal stem cellsDOI 10.1101/2024.07.15.603565
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