Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A genome-wide CRISPR screen identified host genes essential for intracellular Brucella survival

20 Feb 2024

Abstract excerpt

ABSTRACT Brucella is a zoonotic intracellular bacterium that poses threats to human health and economic security. Intracellular infection is a hallmark of the agent Brucella and a primary cause of distress, through which the bacterium regulates the host intracellular environment to promote its own colonization and replication, evading host immunity and pharmaceutical killing. Current studies of Brucella...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brucella: diagnosis, epidemiology, treatment
Share to Burkholderia infections and melioidosis
Share to CRISPR and Genetic Engineering

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38376367
DOI: 10.1128/spectrum.03383-23

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A genome-wide CRISPR screen identified host genes essential for intracellular Brucella survivalPMID 38376367Read ↗

A genome-wide CRISPR screen defines host determinants of early <i>Brucella</i> infection in human macrophage-like cellsSemantic proximity Read ↗

Brucella: functional genomics and host–pathogen interactionsSemantic proximity Read ↗

Genome-wide CRISPR screens and their applications in infectious diseaseSemantic proximity Read ↗

A CRISPR Way to Diagnose Infectious Diseases.Semantic proximity Read ↗

Identification of Mycobacterium tuberculosis intracellular survival-related virulence factors via CRISPR-based eukaryotic-like secretory protein mutant library screenSemantic proximity Read ↗

A Chemical Genetics Screen Reveals Influence of p38 Mitogen-Activated Protein Kinase and Autophagy on Phagosome Development and Intracellular Replication of Brucella neotomae in MacrophagesSemantic proximity Read ↗

A CRISPR interference platform for selective downregulation of gene expression in <i>Borrelia burgdorferi</i>Semantic proximity Read ↗

An evolutionary strategy for a stealthy intracellular <i>Brucella</i> pathogenSemantic proximity Read ↗

Induced protein expression in Leptospira spp. and its application to CRISPR/Cas9 mutant generation.Semantic proximity Read ↗

M. tuberculosis CRISPR/Cas proteins are secreted virulence factors that trigger cellular immune responsesSemantic proximity Read ↗

Genome-wide CRISPR screening identifies TMEM106B as a proviral host factor for SARS-CoV-2Semantic proximity Read ↗

CRISPR-prime editing, a versatile genetic tool to create specific mutations with a single nucleotide resolution in Leptospira.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.