Article

ScFv-h3D6 Prevents Bapineuzumab-Induced Hemorrhagic Events in the APP23 Mouse Model of Alzheimer’s Disease

2025-11-05

Abstract excerpt

The occurrence of amyloid-related imaging abnormalities (ARIA), found in clinical trials for Aβ-immunotherapy, has been related to the antibody’s effector function on glial activation by the Fc portion of the antibody. The use of single chain variable fragments (scFv) has been proposed as a safer therapeutic strategy. Here, effects of the mice format of bapineuzumap (mAb-m3D6) and its scFv (scFv-h3D6) on the occur...

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Literature Corpus work: 975fef8f-0c29-5713-9ca0-c1f5e8deeaae
DOI: 10.20944/preprints202511.0180.v1

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ScFv-h3D6 Prevents Bapineuzumab-Induced Hemorrhagic Events in the APP23 Mouse Model of Alzheimer’s DiseaseDOI 10.20944/preprints202511.0180.v1Read

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