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Article

Chronic Verubecestat Treatment Suppresses Amyloid Accumulation in Advanced Aged Tg2576-AβPPswe Mice Without Inducing Microhemorrhage.

Journal of Alzheimer's disease : JAD - 1 Jan 2017

Villarreal Stephanie, Zhao Fuqiang, Hyde Lynn A, Holder Daniel, Forest Thomas, Sondey Marie, Chen Xia, Sur Cyrille, Parker Eric M, Kennedy Matthew E

Abstract excerpt

Verubecestat is a potent BACE1 enzyme inhibitor currently being investigated in Phase III trials for the treatment of mild-to-moderate and prodromal Alzheimer's disease. Multiple anti-amyloid immunotherapies have been dose-limited by adverse amyloid related imaging abnormalities such as vasogenic edema (ARIA-E) and microhemorrhage (ARIA-H) observed in human trials and mice. Verubecestat was tested in a 12-week...

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Share to Amyloid beta-Peptides
Share to Amyloid beta-Protein Precursor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antibodies, Monoclonal, Humanized

Share to Antipsychotic Agents

Share to Collagen Type IV

Share to Intracranial Hemorrhages

Share to Plaque, Amyloid

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Source

Open in PubMed Open full text

Identifiers

PMID: 28800329
DOI: 10.3233/JAD-170056
PMCID: PMC5611839

Genes

BACE1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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