Back to search

Article

Detection of<i>M. tuberculosis</i>DNA in TB contacts’ PBMC does not associate with blood RNA signatures for incipient tuberculosis

2023-09-26

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> We have previously reported detection of genomic DNA of Mycobacterium tuberculosis (Mtb) in peripheral blood mononuclear cells (PBMC) of asymptomatic adults with recent household exposure to an index case of infectious pulmonary tuberculosis (TB). It is not known whether this phenomenon indicates quiescent Mtb infection or incipient TB disease. <h4>Methods</h4> We did a cross-...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
975a32c1-d6de-5c5e-98b9-07b48f94beb4
DOI
10.1101/2023.09.26.23296131
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Detection of<i>M. tuberculosis</i>DNA in TB contacts’ PBMC does not associate with blood RNA signatures for incipient tuberculosisDOI 10.1101/2023.09.26.23296131
Concise whole blood transcriptional signatures for incipient tuberculosis: A systematic review and patient-level pooled meta-analysisSemantic proximity
Analysis of immunological resistance to primary <i>Mycobacterium tuberculosis</i> infection in humansSemantic proximity
Detection of Mycobacterium tuberculosis complex DNA in CD34-positive peripheral blood mononuclear cells of asymptomatic tuberculosis contacts: an observational studySemantic proximity
Resolution of blood RNA signatures fails to discriminate sputum culture status after eight weeks of tuberculosis treatmentSemantic proximity
A Serum Circulating miRNA Signature for Short-Term Risk of Progression to Active Tuberculosis Among Household ContactsSemantic proximity
A needle in a haystack: metagenomic DNA sequencing to quantify <i>Mycobacterium tuberculosis</i> DNA and diagnose tuberculosisSemantic proximity
Circulating Cell-Free RNA in Blood as a Host Response Biomarker for the Detection of TuberculosisSemantic proximity
Detection of Mycobacterium tuberculosis DNA in CD34+ peripheral blood mononuclear cells of Ugandan adults with latent infection: a cross-sectional and nested prospective studySemantic proximity
Host transcriptional response to TB preventive therapy differentiates two sub-groups of IGRA-positive individualsSemantic proximity
Airway immune signatures of protection and disease progression in recent human tuberculosis household contactsSemantic proximity
Blood RNA biomarkers for tuberculosis screening in people living with HIV prior to anti-retroviral therapy initiation: A diagnostic accuracy studySemantic proximity
A blood RNA transcript signature for TB exposure in household contactsSemantic proximity
Select a neighboring publication to make it the new centre.