Article

Combinations of HDAC inhibitor and PPAR agonist induce ferroptosis of leukemia stem and progenitor cells in acute myeloid leukemia

2023-08-01

Abstract excerpt

<title>Abstract</title> <p>Leukemia stem cells (LSCs) are responsible for leukemia initiation, relapse, and therapeutic resistance. Therefore, the development of novel therapeutic approaches targeting LSCs is urgently needed for patients with AML. Here, we report that the histone deacetylase inhibitor chidamide (CS055), in combination with peroxisome proliferator-activated receptor (PPAR) pan agonist (chiglitazar...

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Literature Corpus work: 974c785f-2622-5abc-ad8c-c26bfd004689
DOI: 10.21203/rs.3.rs-3184293/v1

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