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G-CSF Upregulates the Expression of Aquaporin-9 through CEBPB to Enhance the Cytotoxic Activity of Arsenic Trioxide to Acute Myeloid Leukemia Cells

2022-03-29

Abstract excerpt

<h4>Background: </h4> Arsenic trioxide (ATO) is widely used for acute promyelocytic leukemia (APL) treatment, but it can’t show satisfactory efficacy in non-APL leukemia. Aquaporin-9 (AQP9), a transmembrane transporter, is required for ATO uptake. Acute myeloid leukemia (AML) other than APL cells express relatively lower levels of AQP9, which limits the cytotoxic activity of ATO in those types of leukemia cells. R...

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Literature Corpus work
7161920d-76c8-5b78-8bd6-04cb2295a6e0
DOI
10.21203/rs.3.rs-1423336/v2
Open publication

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G-CSF Upregulates the Expression of Aquaporin-9 through CEBPB to Enhance the Cytotoxic Activity of Arsenic Trioxide to Acute Myeloid Leukemia CellsDOI 10.21203/rs.3.rs-1423336/v2
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