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Article

A 71-Gene Signature of TRAIL Sensitivity in Cancer Cells

25 Oct 2011

Abstract excerpt

TNF-related apoptosis inducing ligand (TRAIL) is a promising anticancer agent because of its ability to selectively induce apoptosis in cancer cells but not in most normal cells. However, some cancer cells are resistant to TRAIL cytotoxicity thereby limiting its therapeutic efficacy. Using genome-wide mRNA expression profiles from the NCI60 panel and their differential sensitivities to TRAIL-induced apoptosis, we...

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PMID: 22027696
DOI: 10.1158/1535-7163.mct-11-0620

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