Article

Brown adipose expansion and remission of glycemic dysfunction in obese SM/J mice

2019-08-05

Abstract excerpt

Disruption of glucose homeostasis increases the risk of type II diabetes, cardiovascular disease, stroke, and cancer. We leverage a novel rodent model, the SM/J mouse, to understand glycemic control in obesity. On a high fat diet, obese SM/J mice initially develop impaired glucose tolerance and elevated fasting glucose. Strikingly, their glycemic dysfunction resolves by 30 weeks of age despite persistence of obesi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 970c798b-0cb7-5e7c-9754-ca3bb128b5aa
DOI: 10.1101/724369

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Brown adipose expansion and remission of glycemic dysfunction in obese SM/J miceDOI 10.1101/724369Read

From Metabolically Healthy to Unhealthy Obesity Through Low-Grade InflammationSemantic proximity Read

Long‐term impact of obesity: Unraveling adipose epigenetic memorySemantic proximity Read

Rapid Remodeling of Human White Adipose Tissue Following Bariatric SurgerySemantic proximity Read

Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissueSemantic proximity Read

Adipose Tissue Macrophage Polarization in Healthy and Unhealthy ObesitySemantic proximity Read

The metabolic response to a high-fat diet reveals obesity-prone and -resistant phenotypes in mice with distinct mRNA-seq transcriptome profiles.Semantic proximity Read

Metabolically healthy and unhealthy obese--the 2013 Stock Conference report.Semantic proximity Read

Multiomics reveals persistence of obesity-associated immune cell phenotypes in adipose tissue during weight loss and subsequent weight regainSemantic proximity Read

Macrophage Phenotypes and Gene Expression Patterns Are Unique in Naturally Occurring Metabolically Healthy Obesity.Semantic proximity Read

Beige Fat Maintenance; Toward a Sustained Metabolic HealthSemantic proximity Read

A low protein diet drives short-and long-term improvements in metabolic health in a mouse model of sleeve gastrectomySemantic proximity Read

Obesity-associated improvements in metabolic profile through expansion of adipose tissue.Semantic proximity Read