The Identification by Shotgun Proteomics with High-Resolution Tandem Mass-Spectrometry of Histone Isoforms' Hypermethylation Phenotype as a Hallmark Characteristic of Human-IDH-Mutant High-Grade Gliomas: Epigenetic Applications for Genotoxicity-Based Biomarkers and Cancer Therapy Targets.

doi:10.1021/acs.jproteome.5c00158

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The Identification by Shotgun Proteomics with High-Resolution Tandem Mass-Spectrometry of Histone Isoforms' Hypermethylation Phenotype as a Hallmark Characteristic of Human-IDH-Mutant High-Grade Gliomas: Epigenetic Applications for Genotoxicity-Based Biomarkers and Cancer Therapy Targets.

Journal of proteome research - 5 Sept 2025

Louati Kaouthar, Kolsi Fatma, Mellouli Manel, Louati Hanen, Zribi Rania, Kallel Rim, Borni Mahdi, Gdoura Yassine, Hakim Leila Sellami, Maalej Amina, Choura Sirine, Chamkha Mohamed, Sayadi Sami, Mnif Basma, Khemakhem Zouheir, Boudawara Tahya Sellami, Boudawara Mohamed Zaher, Bouraoui Abderrahman, Kraiem Jamil, Safta Fathi

Abstract excerpt

Histone post-translational modifications (PTMs) have been linked to various pathological processes, especially in cancer onset, where they are envisaged as obvious diagnostic biomarkers and pivotal predictors for pathological prognosis. Consequently, their mapping and characterization constitute a critical field of study facilitated by recent advances in the high-throughput mass spectrometry technique. The...

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PMID: 40679821
DOI: 10.1021/acs.jproteome.5c00158
PMCID: PMC12418497

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The Identification by Shotgun Proteomics with High-Resolution Tandem Mass-Spectrometry of Histone Isoforms' Hypermethylation Phenotype as a Hallmark Characteristic of Human-IDH-Mutant High-Grade Gliomas: Epigenetic Applications for Genotoxicity-Based Biomarkers and Cancer Therapy Targets.PMID 40679821Read ↗

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