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Desmoplastic Small Round Cell Tumor

12 Sept 2016

Abstract excerpt

Desmoplastic small round cell tumor (DSRCT) is an aggressive small round cell neoplasm which predominantly occurs intra-abdominally in adolescents and young adults with a male predominance, and which is characterized by a recurrent t(11;22)(p13;q12) translocation leading to formation of the EWSR1-WT1 fusion gene, which generates a chimeric protein with transcriptional regulatory activity. Histologically, DSRCT...

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PMID: 27621277
DOI: 10.1177/1066896916668637

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