Article
Analysis of SARS-CoV-2 omicron mutations that emerged during long-term replication in a lung cancer xenograft mouse model.
Virus genes - 1 Jun 2024
Baek Kyeongbin, Kim Dongbum, Kim Jinsoo, Kang Bo Min, Park Heedo, Park Sangkyu, Shin Ha-Eun, Lee Myeong-Heon, Maharjan Sony, Kim Minyoung, Kim Suyeon, Park Man-Seong, Lee Younghee, Kwon Hyung-Joo
Abstract excerpt
SARS-CoV-2 Omicron has the largest number of mutations among all the known SARS-CoV-2 variants. The presence of these mutations might explain why Omicron is more infectious and vaccines have lower efficacy to Omicron than other variants, despite lower virulence of Omicron. We recently established a long-term in vivo replication model by infecting Calu-3 xenograft tumors in immunodeficient mice with parental...
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