High genome plasticity and frequent genetic exchange in Leishmania tropica isolates from Afghanistan, Iran and Syria.

doi:10.1371/journal.pntd.0010110

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Article

High genome plasticity and frequent genetic exchange in Leishmania tropica isolates from Afghanistan, Iran and Syria.

PLoS neglected tropical diseases - 1 Dec 2021

Glans Hedvig, Lind Karlberg Maria, Advani Reza, Bradley Maria, Alm Erik, Andersson Björn, Downing Tim

Abstract excerpt

BACKGROUND: The kinetoplastid protozoan Leishmania tropica mainly causes cutaneous leishmaniasis in humans in the Middle East, and relapse or treatment failure after treatment are common in this area. L. tropica's digenic life cycle includes distinct stages in the vector sandfly and the mammalian host. Sexual reproduction and genetic exchange appear to occur more frequently than in other Leishmania species....

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PMID: 34968388
DOI: 10.1371/journal.pntd.0010110
PMCID: PMC8754299

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