Article

Parallel multiOMIC analysis reveals glutamine deprivation enhances directed differentiation of renal organoids

2025-03-01

Abstract excerpt

Metabolic pathways play a critical role in driving differentiation but remain poorly understood in the development of kidney organoids. In this study, parallel metabolite and transcriptome profiling of differentiating human pluripotent stem cells (hPSCs) to multicellular renal organoids revealed key metabolic drivers of the differentiation process. In the early stage, transitioning from hPSCs to nephron progenitor...

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Literature Corpus work: 9693cf1e-119d-580e-a1e4-1aedb48d0166
DOI: 10.1101/2025.02.27.640060

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