Article

A yeast model of Bloom's syndrome

1999-01-01

Abstract excerpt

Bloom's syndrome (BS) is a rare inherited disorder associated with growth retardation, immunodeficiency and a predisposition to cancers of all types. At a cellular level BS is associated with marked chromosomal instability, as manifest by interchanges between homologous chromosomes and sister chromatids. BS arises as a consequence of defects in a DNA helicase, BLM, which is a member of the RecQ family of helicases...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 967e2a7e-47ff-54a9-a1c8-a632d58053f8
DOI: 10.21954/ou.ro.00010208

Open publication

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Click a neighbor to travelStep 1 · 12 closest

A yeast model of Bloom's syndromeDOI 10.21954/ou.ro.00010208Read

The DNA helicase activity of BLM is necessary for the correction of the genomic instability of bloom syndrome cells.Semantic proximity Read

[Bloom syndrome].Semantic proximity Read

Bloom's and Werner's syndrome genes suppress hyperrecombination in yeast sgs1 mutant: implication for genomic instability in human diseases.Semantic proximity Read

An essential DNA strand-exchange activity is conserved in the divergent N-termini of BLM orthologs.Semantic proximity Read

Elevation of sister chromatid exchange in Saccharomyces cerevisiae sgs1 disruptants and the relevance of the disruptants as a system to evaluate mutations in Bloom's syndrome gene.Semantic proximity Read

Homologous recombination is responsible for cell death in the absence of the Sgs1 and Srs2 helicases.Semantic proximity Read

Vertebrate WRNIP1 and BLM are required for efficient maintenance of genome stability.Semantic proximity Read

SGS1, a homologue of the Bloom's and Werner's syndrome genes, is required for maintenance of genome stability in Saccharomyces cerevisiae.Semantic proximity Read

Non-Bloom syndrome-associated partial and total loss-of-function variants of BLM helicase.Semantic proximity Read

RECQ-like helicases Sgs1 and BLM regulate R-loop–associated genome instabilitySemantic proximity Read

Bloom's syndrome gene suppresses premature ageing caused by Sgs1 deficiency in yeast.Semantic proximity Read

Genetic analysis of the Saccharomyces cerevisiae Sgs1 helicase defines an essential function for the Sgs1-Top3 complex in the absence of SRS2 or TOP1.Semantic proximity Read