Article

Engineering highly multivalent sperm-binding IgG antibodies for potent non-hormonal female contraception

2020-04-24

Abstract excerpt

Many women risk unintended pregnancy due to dissatisfaction with available hormonal contraceptive methods. This led us to pursue topical sperm-binding monoclonal antibodies as a strategy for safe, non-hormonal contraception. Motivated by the greater agglutination potencies of polymeric immunoglobulins such as IgM and the exceptional bioprocessing ease in manufacturing IgG, we engineered IgGs possessing 6-10 Fabs a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8c212ad1-7a67-5b68-8599-298bc5f9221e
DOI: 10.1101/2020.04.22.055301

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Engineering highly multivalent sperm-binding IgG antibodies for potent non-hormonal female contraceptionDOI 10.1101/2020.04.22.055301Read

Contraceptive vaccines targeting spermSemantic proximity Read

Antisperm Contraceptive Vaccines: Where We Are and Where We Are Going?Semantic proximity Read

Role of Antisperm Antibodies in Infertility, Pregnancy, and Potential for Contraceptive and Antifertility Vaccine Designs: Research Progress and Pioneering VisionSemantic proximity Read

Anti‐Sperm Antibodies from Infertile Patients and their Cognate Sperm Antigens: A Review. Identity Between SAGA‐1, the H6‐3C4 Antigen, and CD52Semantic proximity Read

Maternofetal transplacental transport of recombinant IgG antibodies lacking effector functionsSemantic proximity Read

Modalities for Treatment of Antisperm Antibody Mediated Infertility: Novel PerspectivesSemantic proximity Read

Antisperm Antibodies: Invaluable Tools Toward the Identification of Sperm Proteins Involved in FertilizationSemantic proximity Read

Biochemical Characterization of Sperm Agglutination Antigen-1, a Human Sperm Surface Antigen Implicated in Gamete Interactions1Semantic proximity Read

Diagnosis and treatment of immunologically infertile women with sperm-immobilizing antibodies in their sera.Semantic proximity Read

Vaccine for contraception targeting spermSemantic proximity Read

Semen amyloids participate in spermatozoa selection and clearanceSemantic proximity Read

Increased Conception Rates in Beef Cattle Inseminated with Nanopurified Bull Semen1Semantic proximity Read