Article

Both CD8+ and CD4+ T regulatory cells are associated with poor survival in colorectal cancer

2026-08-20

Abstract excerpt

Abstract Previous studies in colorectal cancer have linked high levels of FoxP3 + regulatory T-cells (Treg) (CRC) to favourable prognosis. However, this contradicts the well-established immunosuppressive function of Treg. We resolved this conundrum using multiplex immunohistochemistry to characterise Foxp3+and IL-10+ Treg in 1,000, consecutively recruited patients’ tumours. Although Foxp3+ cells associated with im...

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Literature Corpus work: 96364689-2ce9-5ba3-8cdc-63d3470c80ea
DOI: 10.1038/s41698-026-01660-2

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