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Single-cell analysis reveals an antiviral network that controls Zika virus infection in human dendritic cells

3 Apr 2024

Abstract excerpt

Zika virus (ZIKV) is a mosquito-borne flavivirus that caused an epidemic in the Americas in 2016 and is linked to severe neonatal birth defects, including microcephaly and spontaneous abortion. To better understand the host response to ZIKV infection, we adapted the 10× Genomics Chromium single-cell RNA sequencing (scRNA-seq) assay to simultaneously capture viral RNA and host mRNA. Using this assay, we profiled...

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PMID: 38567950
DOI: 10.1128/jvi.00194-24

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