Article

Mathematical Modeling of AA Amyloidosis: Coupling SAA-HDL Binding Dynamics with Path-Dependent Renal Aging

2026-02-20

Abstract excerpt

AA amyloidosis is a severe complication of chronic inflammatory diseases characterized by fibrillar protein deposition in the kidneys, leading to progressive organ failure. This study presents a mathematical model that couples SAA-HDL binding dynamics with renal amyloid aggregation kinetics to investigate the pathogenesis of AA amyloidosis. Under normal physiological conditions, Serum Amyloid A (SAA) circulates pr...

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Literature Corpus work: 960d241f-8aee-5f4c-aad3-bee268c633c5
DOI: 10.64898/2026.02.19.706923

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