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Article

Allele-selective inhibition of huntingtin expression by switching to an miRNA-like RNAi mechanism.

Chemistry & biology - 24 Nov 2010

Hu Jiaxin, Liu Jing, Corey David R

Abstract excerpt

Inhibiting expression of huntingtin (HTT) protein is a promising strategy for treating Huntington's disease (HD), but indiscriminant inhibition of both wild-type and mutant alleles may lead to toxicity. An ideal silencing agent would block expression of mutant HTT while leaving expression of wild...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21095568
DOI: 10.1016/j.chembiol.2010.10.013
PMCID: PMC3021381

Genes

HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21095568-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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