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Article

Self-duplexing CUG repeats selectively inhibit mutant huntingtin expression.

Nucleic acids research - 1 Dec 2013

Fiszer Agnieszka, Olejniczak Marta, Galka-Marciniak Paulina, Mykowska Agnieszka, Krzyzosiak Wlodzimierz J

Abstract excerpt

Huntington's disease (HD) is a neurodegenerative genetic disorder caused by the expansion of the CAG repeat in the translated sequence of the HTT gene. This expansion generates a mutant huntingtin protein that contains an abnormally elongated polyglutamine tract, which, together with mutant transcript, causes cellular dysfunction. Currently, there is no curative treatment available to patients suffering from HD;...

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Identifiers

PMID: 24038471
DOI: 10.1093/nar/gkt825
PMCID: PMC3905887

Genes

HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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