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Article

The therapeutic potential of siRNA in gene therapy of neurodegenerative disorders.

Journal of neural transmission. Supplementum - 1 Jan 2007

Koutsilieri E, Rethwilm A, Scheller C

Abstract excerpt

RNA interference using small inhibitory RNA (siRNA) has become a powerful tool to downregulate mRNA levels by cellular nucleases that become activated when a sequence homology between the siRNA and a respective mRNA molecule is detected. Therefore siRNA can be used to silence genes involved in the pathogenesis of various diseases associated with a known genetic background. As for many neurodegenerative disorders...

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PMID: 17982877
DOI: 10.1007/978-3-211-73574-9_7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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