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Dissecting CD8+ T cell pathology of severe SARS-CoV-2 infection by single-cell immunoprofiling

16 Dec 2022

Abstract excerpt

Introduction SARS-CoV-2 infection results in varying disease severity, ranging from asymptomatic infection to severe illness. A detailed understanding of the immune response to SARS-CoV-2 is critical to unravel the causative factors underlying differences in disease severity and to develop optimal vaccines against new SARS-CoV-2 variants. Methods We combined single-cell RNA and T cell receptor sequencing with...

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PMID: 36591270
DOI: 10.3389/fimmu.2022.1066176

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