Article

A unique cytotoxic CD4<sup>+</sup>T cells signature defines critical COVID-19

2023-02-23

Abstract excerpt

<h4>Background and objectives</h4> SARS-CoV-2 infection causes a spectrum of clinical disease presentation, ranging from asymptomatic to fatal. While neutralising antibody (NAb) responses correlate with protection against symptomatic and severe infection, the contribution of the T cell response to the resolution or progression of disease is still unclear. Optimal protective immunity may require activation of disti...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 23e95ae8-4649-529c-9642-60c774e69a1f
DOI: 10.1101/2023.02.17.23286059

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A unique cytotoxic CD4<sup>+</sup>T cells signature defines critical COVID-19DOI 10.1101/2023.02.17.23286059Read

A unique cytotoxic CD4 + T cell‐signature defines critical COVID‐19Semantic proximity Read

Comprehensive longitudinal profiling of SARS-CoV-2-specific CD8 <sup>+</sup> T-cells reveal strong functional impairment and recognition bias as markers for disease severitySemantic proximity Read

Robust T cell immunity in convalescent individuals with asymptomatic or mild COVID-19Semantic proximity Read

TCR signatures following SARS-CoV-2 infection correlate with clinical symptoms and post-acute sequelae of COVID-19Semantic proximity Read

Distinct CD8 <sup>+</sup> T-cell types Associated with COVID-19 Severity in Unvaccinated HLA-A2 <sup>+</sup> PatientsSemantic proximity Read

Single-Cell Transcriptomic Analysis of SARS-CoV-2 Reactive CD4 <sup>+</sup> T CellsSemantic proximity Read

An open resource for T cell phenotype changes in COVID-19 identifies IL-10-producing regulatory T cells as characteristic of severe casesSemantic proximity Read

Multiomic Immunophenotyping of COVID-19 Patients Reveals Early Infection TrajectoriesSemantic proximity Read

Identification and characterization of a SARS-CoV-2 specific CD8+ T cell response with immunodominant features.Semantic proximity Read

SARS-CoV-2 genome-wide T cell epitope mapping reveals immunodominance and substantial CD8 + T cell activation in COVID-19 patientsSemantic proximity Read

Identification of Distinct Immune Cell Subsets Associated With Asymptomatic Infection, Disease Severity, and Viral Persistence in COVID-19 PatientsSemantic proximity Read

A possible role of immunopathogenesis in COVID-19 progressionSemantic proximity Read