Article

Inhibition of Indirect Pathway Activity Causes Abnormal Decision-Making In a Mouse Model of Impulse Control Disorder in Parkinson’s Disease

2024-02-22

Abstract excerpt

<h4>ABSTRACT</h4> Healthy action selection relies on the coordinated activity of striatal direct and indirect pathway neurons. In Parkinson’s disease (PD), in which loss of midbrain dopamine neurons is associated with progressive motor and cognitive deficits, this coordination is disrupted. Dopamine replacement therapy can remediate motor symptoms, but can also cause impulse control disorder (ICD), which is chara...

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Literature Corpus work: 95ef6f3e-4482-528c-982b-6da8bfad3210
DOI: 10.1101/2024.02.19.581062

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