Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The indirect basal ganglia pathway in dopamine D(2) receptor-deficient mice.

Neuroscience - 1 Jan 2000

Murer M G, Dziewczapolski G, Salin P, Vila M, Tseng K Y, Ruberg M, Rubinstein M, Kelly M A, Grandy D K, Low M J, Hirsch E, Raisman-Vozari R, Gershanik O

Abstract excerpt

Recent pathophysiological models of basal ganglia function in Parkinson's disease predict that specific neurochemical changes in the indirect pathway would follow the lack of stimulation of D(2) dopamine receptors. Post mortem studies of the basal ganglia in genetically modified mice lacking functional copies of the D(2) dopamine receptor gene allowed us to test these predictions. When compared with their...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Electron Transport Complex IV
Share to Globus Pallidus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glutamate Decarboxylase

Share to Neostriatum

Share to Neural Pathways

Share to Receptors, Dopamine D2

Share to Substance P

Share to Substantia Nigra

Source

Identifiers

PMID: 10974427
DOI: 10.1016/s0306-4522(00)00223-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The indirect basal ganglia pathway in dopamine D(2) receptor-deficient mice.PMID 10974427Read ↗

Altered striatal function in a mutant mouse lacking D1A dopamine receptors.Semantic proximity Read ↗

Neuronal degeneration in the basal ganglia and loss of pallido-subthalamic synapses in mice with targeted disruption of the Huntington's disease geneSemantic proximity Read ↗

Mutational and biochemical analysis of dopamine in dystonia: evidence for decreased dopamine D2 receptor inhibition.Semantic proximity Read ↗

Dopamine D2 receptors regulate the anatomical and functional balance of basal ganglia circuitry.Semantic proximity Read ↗

Targeted expression of a toxin gene to D1 dopamine receptor neurons by cre-mediated site-specific recombination.Semantic proximity Read ↗

Striatal Neurons Partially Expressing a Dopaminergic Phenotype: Functional Significance and Regulation.Semantic proximity Read ↗

Knockdown of GAD67 protein levels normalizes neuronal activity in a rat model of Parkinson's diseaseSemantic proximity Read ↗

Phenotype of striatofugal medium spiny neurons in parkinsonian and dyskinetic nonhuman primates: a call for a reappraisal of the functional organization of the basal ganglia.Semantic proximity Read ↗

Inhibition of Indirect Pathway Activity Causes Abnormal Decision-Making In a Mouse Model of Impulse Control Disorder in Parkinson’s DiseaseSemantic proximity Read ↗

Normal nigrostriatal innervation but dopamine dysfunction in mice carrying hypomorphic tyrosine hydroxylase alleles.Semantic proximity Read ↗

Involvement of Striatal Cholinergic Interneurons and M1 and M4 Muscarinic Receptors in Motor Symptoms of Parkinson's Disease.Semantic proximity Read ↗

Dopamine receptor and transporter levels are altered in the brain of Purkinje Cell Degeneration mutant mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.