Article

Stoichiometry of HIV-1 Envelope Glycoprotein Protomers with Changes That Stabilize or Destabilize the Pretriggered Conformation

2024-10-27

Abstract excerpt

<h4>ABSTRACT</h4> During human immunodeficiency virus (HIV-1) entry into host cells, binding to the receptors, CD4 and CCR5/CXCR4, triggers conformational changes in the metastable envelope glycoprotein (Env) trimer ((gp120-gp41) 3 ). CD4 binding induces Env to make transitions from its pretriggered conformation (PTC) to more “open” conformations that are sensitive to inhibition by antibodies, CD4-mimetic compou...

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Literature Corpus work: 0d599de2-a1f6-50c9-9dfa-232d90e908da
DOI: 10.1101/2024.10.25.620268

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