Article

Are improper kinetic models hampering drug development?

2014-10-02

Abstract excerpt

Reproducibility of biological data is a significant problem in research today. One potential contributor to this, which has received little attention, is the over complication of enzyme kinetic inhibition models. This over complication of inhibitory models stems from the common use of the inhibitory term (1+[I]/K i ), an equilibrium binding term that does not distinguish between inhibitor binding and inhibitory e...

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Literature Corpus work: 956cbf5e-de49-54cc-a1a8-69c129577c70
DOI: 10.7287/peerj.preprints.521v1

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