Article

Loss of Fanconi anemia proteins causes a reliance on lysosomal exocytosis

2025-01-24

Abstract excerpt

Mutations in the FA pathway lead to a rare genetic disease that increases risk of bone marrow failure, acute myeloid leukemia, and solid tumors. FA patients have a 500 to 800-fold increase in head and neck squamous cell carcinoma compared to the general population and the treatment for these malignancies are ineffective and limited due to the deficiency in DNA damage repair. Using unbiased CRISPR-interference scre...

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Literature Corpus work: 956b2605-c380-5a52-b1c1-48f933b7e607
DOI: 10.1101/2025.01.23.634631

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