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Aneuploidy triggers a TFEB-mediated lysosomal stress response

17 Nov 2015

Abstract excerpt

Aneuploidy, defined as an alteration in chromosome number that is not a multiple of the haploid complement, severely affects cellular physiology. Changes in chromosome number lead to imbalances in cellular protein composition, thus disrupting cellular processes and causing proteins to misfold and aggregate. We recently reported that in mammalian cells protein aggregates are readily encapsulated within...

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PMID: 26571033
DOI: 10.1080/15548627.2015.1110670

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