Article
Recent advances in targeted degradation in the RAS pathway.
Future medicinal chemistry - 1 Mar 2025
Ge Zhiming, Fan Zisheng, He Wei, Zhou Guizhen, Zhou Yidi, Zheng Mingyue, Zhang Sulin
Abstract excerpt
RAS (rat sarcoma) is one of the most frequently mutated gene families in cancer, encoding proteins classified as small GTPases. Mutations in RAS proteins result in abnormal activation of the RAS signaling pathway, a key driver in the initiation and progression of various malignancies. Consequently, targeting RAS proteins and the RAS signaling pathway has become a critical strategy in anticancer therapy. While RAS...
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