Benchmarking niche identification via domain segmentation for spatial transcriptomics data

Abstract excerpt

Tissue niches are spatially organized microenvironments in which coordinated multicellular interactions shape cellular states and biological functions. Currently, niche identification is routinely performed using domain segmentation frameworks. While interrelated, spatial domains and niches are not fundamentally equivalent. The former emphasizes intra-domain compositional consistency and transcriptomic homogeneity...

Topics

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• Algorithms
• Biomarkers, Tumor
• Gene Expression Regulation, Neoplastic
• Microscopy
• Neoplasms
• Phenotype
• Radiomics and Machine Learning in Medical Imaging
• Single-Cell Gene Expression Analysis

Identifiers and source

Literature Corpus work

94ee75fd-8600-5d4e-968e-a383fdcce02a

DOI

10.64898/2026.02.27.708202