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Stable Cell Clones Harboring Self-Replicating SARS-CoV-2 RNAs for Drug Screen

26 Jan 2022

Abstract excerpt

SARS-CoV-2 replicon systems that have been reported up to date were unsuccessful in deriving stable cell lines harboring non-cytopathic replicons. The transient expression of viral sgmRNA or a reporter gene makes it impractical for industry-scale screening of large compound libraries using these systems. Here, for the first time, we derived stable cell clones harboring the SARS-CoV-2 replicon. These clones may...

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PMID: 35080424
DOI: 10.1128/jvi.02216-21

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