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Article

Synaptic dysfunction and altered excitability in C9ORF72 ALS/FTD.

Brain research - 15 Aug 2018

Starr Alexander, Sattler Rita

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is characterized by a progressive degeneration of upper and lower motor neurons, resulting in fatal paralysis due to denervation of the muscle. Due to genetic, pathological and symptomatic overlap, ALS is now considered a spectrum disease together with frontotemporal dementia (FTD), the second most common cause of dementia in individuals under the age of 65. Interestingly, in...

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PMID: 29453960
DOI: 10.1016/j.brainres.2018.02.011
PMCID: PMC5997509

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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