Article

ERAP2 increases the abundance of a peptide submotif highly selective for the Birdshot Uveitis-associated HLA-A29

2020-08-14

Abstract excerpt

<h4>ABSTRACT</h4> Birdshot Uveitis (BU) is a blinding inflammatory eye condition that only affects HLA-A29-positive individuals. Genetic association studies linked ERAP2 with BU, an aminopeptidase which trims peptides before their presentation by HLA class I at the cell surface, which suggests that ERAP2-dependent peptide presentation by HLA-A29 drives the pathogenesis of BU. However, it remains poorly understoo...

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Literature Corpus work: 94b96a5f-a387-54d8-a406-0a3e2931fe01
DOI: 10.1101/2020.08.14.250654

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