Article
Modulation of Natural HLA-B*27:05 Ligandome by Ankylosing Spondylitis-associated Endoplasmic Reticulum Aminopeptidase 2 (ERAP2).
Molecular & cellular proteomics : MCP - 1 Jun 2020
Lorente Elena, Fontela Miguel G, Barnea Eilon, Martín-Galiano Antonio J, Mir Carmen, Galocha Begoña, Admon Arie, Lauzurica Pilar, López Daniel
Abstract excerpt
The HLA-B*27:05 allele and the endoplasmic reticulum-resident aminopeptidases are strongly associated with AS, a chronic inflammatory spondyloarthropathy. This study examined the effect of ERAP2 in the generation of the natural HLA-B*27:05 ligandome in live cells. Complexes of HLA-B*27:05-bound peptide pools were isolated from human ERAP2-edited cell clones, and the peptides were identified using high-throughput...
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